The position of Ca 2+ ions in excitation-contraction coupling of skeletal muscle fibres. Writer hyperlinks open overlay panel W. Melzer 1 A. Herrmann-Frank 1 H.Ch. Lüttgau
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Key phrases myocardial ischemia, coronary blood circulation, cardiac operate, cardiac metabolism, myocardial infarction, cardiac reworking, irritation, fibrosis, angina pectoris, myocardial hibernation Copyright © 2012 Elsevier Inc. All rights reserved.
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Muscle Elementary Biology and Mechanisms of Illness 2012, Pages 495–521 Quantity 1 Edited By Joseph A. Hill and Eric N. Olson Abstract Myocardial ischemia, an imbalance between myocardial blood provide and demand, is the hallmark of the medical syndromes of ischemic coronary heart illness (IHD). The manifestations of IHD are depending on the severity, acuity, and period of the ischemic episodes starting from acute myocardial infarction to continual ischemic cardiomyopathy and angina pectoris.
This chapter first discusses the basic metabolic, purposeful, and ionic disturbances occurring within the myocardium following ischemia. Subsequently, we describe the reparative indicators triggered within the infarcted coronary heart and the molecular pathways resulting in scar formation and ventricular transforming. Lastly, we talk about the mechanistic foundation of the manifestations of persistent IHD, together with ischemic cardiac fibrosis, myocardial hibernation, and angina pectoris.